Bayer Heathcare Drontal Dog Tasty Bone XL Wormer Tablets

Drontal Dog Tasty Bone XL Wormer Tablets

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Note: Currently not available for delivery to Northern Ireland, Channel Islands, Ireland Republic, EU 1, EU 2, EU 3, EU 4, EU 5, EU 6, EU 7, EU 8, Global 1 and USA.

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Drontal Dog Tasty Bone XL Wormer Tablets for the control of the following gastrointestinal roundworms and tapeworms of dogs and puppies.

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Drontal Dog Tasty Bone XL Flavour Tablets are pale brown to brown oval-shaped divisible tablets scored on both sides containing 175 mg praziquantel, 504 mg pyrantel embonate and 525 mg febantel as active constituents and 408.0 mg Artificial beef flavour irradiated.





For the control of the following gastrointestinal roundworms and tapeworms of dogs and puppies.


Toxocara canis, Toxascaris leonina (adult and late immature forms).


Uncinaria stenocephala, Ancylostoma caninum (adults).


Trichuris vulpis (adults).


Echinococcus species, Taenia species, Dipylidium caninum (adults and immature forms).


Dosage and administration
For oral administration only.
The recommended dose rate is: 15 mg/kg body weight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel.
This is equivalent to 1 Drontal Plus XL Flavour Tablet per 35 kg bodyweight as follows:
Dosage Guide
Drontal Plus XL Flavour Tablets
17.5 kg body weight = ½ tablet
>17.5 - 35 kg body weight = 1 tablet
>35 - 52.5 kg body weight = 1½ tablets
>52.5 - 70 kg body weight = 2 tablets
Drontal Dog Tasty Bone Tablets should be used to achieve accurate dosing in dogs weighing less than 17.5 kg. The dose of Drontal Dog Tasty Bone Tablets is equivalent to 1 tablet per 10 kg.
Oral administration: the tablet(s) can be given directly to the dog or disguised in food. No starvation is needed before or after treatement.
For routine treatment a single dose is recommended.
For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning.
For routine control adult dogs should be treated every 3 months. In the event of heavy roundworm infection a repeat dose should be given after 14 days.

Use During Pregnancy and Lactation
Consult a veterinary surgeon before treating pregnant animals for roundworms.
The product may be used during lactation.
Do not exceed the recommended dose when treating pregnant bitches.


Contra-indications, warnings, etc
Do not use simultaneously with piperazine compounds.
Concurrent use with other cholinergic compounds is not recommended.
In very rare cases slight and transient digestive tract disorders such as vomiting and/or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia or hyperactivity.
Drontal Plus XL Flavour Tablets are well tolerated in dogs. In safety studies doses of 5 x or greater gave rise to occasional vomiting.
Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
Since it contains praziquantel, the product is effective against Echinococcus multilocularis, which does not occur in the UK or Ireland but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK and Ireland, it is recommended that all dogs entering the country be treated with praziquantel.
User safety
In case of accidental ingestion, seek medical advice and show package leaflet to the physician.
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.
Environmental safety
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.


Pharmaceutical precautions
Do not store above 25°C.
Any part-used tablets should be discarded.
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years. 


Legal category
Legal category: NFA-VPS

Further information
Pharmacotherapeutic group: Anthelmintics, tetrahydropyrimidine. ATC VetCode: QP52AF30.
The product contains three active substances active against roundworms and tapeworms: 1. Febantel, a probenzimidazole, 2. Pyrantel embonate (pamoate) a tetrahydropyrimidine derivative, 3. Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative.
In this fixed combination product pyrantel and febantel act synergistically against relevant nematodes (ascarids, hookworms and whipworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis.
The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular all Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against adult and immature forms of these parasites.
Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastrointestinal (GI) system by peristalsis.
Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.

Marketing Authorisation Number
Vm 00010/4153

GTIN description:Drontal Plus XL Flavour Tablets (2 Tablets)

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