Drontal Dog Tasty Bone Wormer Tablets


Product Description

Drontal Dog Tasty Bone Wormer Tablets single dose dog wormer for roundworm and tapeworm.


Drontal Dog Tasty Bone 150/144/50 mg Tablets
For the treatment of mixed infections by the following species of nematodes and cestodes in dogs:
Ascarids (adult and late immature forms):
Toxocara canis, Toxascaris leonina
Hookworms (adults):
Uncinaria stenocephala, Ancylostoma caninum
Whipworms (adults):
Trichuris vulpis
Tapeworms (adult and immature forms)
Echinococcus granulosus, Echinococcus multilocularis, Dipylidium caninum, Taenia spp


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Link to Veterinary Medicines Suspected Adverse Reaction Scheme

                                            Data Sheet Information


Drontal Dog Tasty Bone 150/144/50 mg tablets are light-brown to brown, meat flavoured, bone shaped tablets scored on both sides that can be divided into halves. Each tablet contains 150 mg febantel, 50 mg pyrantel (equivalent to 144 mg pyrantel embonate) and 50 mg praziquantel



Dosage: For treatment of dogs administer 1 tablet per 10 kg body weight (15 mg febantel, 14.4 mg pyrantel embonate and 5 mg praziquantel/kg body weight).
Bodyweight (kg)            Tablet Quantity

2 - 5                                    1/2 tablet

5 - 10                                  1  tablet

10 - 15                                1 1/2 tablet

15 - 20                                2 tablets

For each additional 5 kg body weight, administer an additional half tablet


The tablets are flavoured and studies have shown that they are palatable and are taken voluntarily by the majority (88%) of dogs tested.
The tablets can be administered with or without food. Access to normal diet does not need to be limited before or after treatment.
Tablets should be given as a single administration.
The advice of a veterinarian should be sought regarding the need for and frequency of repeat treatment.
Not for use in dogs weighing less than 2 kg.

Further Information

Pharmacotherapeutic group: Anthelmintics, praziquantel combinations.

ATCvet code: QP52AA51.
The product is an anthelmintic containing as active substances the tetrahydropyrimidine derivative pyrantel (as the embonate salt), the pro-benzimidazole febantel and praziquantel, a partly hydrogenated pyrazinoisoquinoline derivative. It is effective against certain roundworms and tapeworms.
In this fixed combination pyrantel and febantel act synergistically against roundworms (ascarids, hookworms and whipworms) in dogs. In particular, the action spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, and Trichuris vulpis.
The spectrum of activity of praziquantel covers tapeworm species in dogs. In particular, it includes all Taeniaspecies, as well as Multiceps multiceps, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against all intestinal stage of these parasites.
Pyrantel acts as the nicotine, as a cholinergic agonist, causing spastic paralysis of roundworms via a depolarising neuromuscular block.
The anthelmintic efficacy of febantel is due to its ability to inhibit the polymerisation of tubuline to microtubuli. The resulting structural and functional metabolic disturbances exhaust the parasite’s energy reserves and kill it in 2-3 days.
Praziquantel is absorbed very rapidly through the parasite’s surfaces and is evenly distributed throughout their bodies. It causes severe damage of their integument, leading to disruption of metabolism and thence to death.
Praziquantel is absorbed almost completely in the small intestine following oral administration to dogs. Absorption is very rapid reaching maximum serum levels within 0.5 to 2 hours. After absorption, the drug is widely distributed through the body. Plasma protein binding is high. Praziquantel is rapidly metabolised in the liver leading to inactive metabolites. In dogs, metabolites are eliminated by urine (66 % of an oral dose) and via the bile (15%) in the faeces. Elimination half-life in dogs is about 3 hours.
Pyrantel (as embonate), being a low water-soluble compound, is poorly absorbed in the gastrointestinal tract, reaching the final parts of the intestine. The absorbed drug is extensively metabolised and the parent compound/metabolites are excreted by urine. Febantel is a pro-drug that after oral administration and oral absorption is metabolised to fenbendazole and oxfendazole, the chemical entities exerting the anthelmintic effect. The active metabolites are excreted via faeces.



Teratogenic effects attributed to high doses of febantel administered during early pregnancy have been reported in rats, sheep and dogs.
The safety of the product has not been investigated during the 1st and 2nd third of pregnancy. Do not use in pregnant dogs during the 1st and 2nd third of pregnancy (see Contra-Indications, Warnings etc).
A single treatment during the last third of pregnancy or during lactation has been demonstrated safe.
Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Do not use during the 1st and 2nd third of pregnancy.
Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
To minimise the risk of re-infestation and new infestation, excreta should be collected and properly disposed of for 24 hours following treatment.
In very rare cases mild and transient digestive tract disorders (e.g. vomiting) may occur.
The frequency of adverse reactions is defined using the following convention:
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
The anthelmintic effects of this product and piperazine containing products may be antagonised when the two drugs are used together.
10 times the recommended dose of the product was tolerated without signs of adverse reactions in dogs and pups.
Since it contains praziquantel, the product is effective against Echinococcus spp. which do not occur in all EU member states but are becoming more common in some. Echinococcosis represents a hazard for humans. As echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.
User Safety
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. In the interests of good hygiene, persons administering the product directly to a dog or by adding it to the dog’s food should wash their hands afterwards.
Environmental Safety
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Drontal Dog Tasty Bone Wormer Tablets

Legal Status: NFA - VPS

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